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RevistaJBIC
Año2007
Volumen12
Páginas751-760
Internacional

Activation and Inactivation of Hydrogenase Function and the Catalytic Cycle: Spectroelectrochemical Studies

Autores:Alejandro Pardo Honrubia, Antonio López de Lacey, Víctor Manuel Fernández López, Yubo Fan , Michael B. Hall
Grupos de investigación:BioElectroCatálisis
The inactive forms, unready (Ni-A, Ni-SU) and ready (Ni-B), of NiFe hydrogenases are modeled by examining the possibility of hydroxo, oxo, hydroperoxo, peroxo, and sulfenate groups in active-site models and comparing predicted IR frequencies and g tensors with those of the enzyme. The best models for Ni-A and Ni-SU have hydroxo (μ-OH) bridges between Fe and Ni and a terminal sulfenate [Ni–S(=O)Cys] group, although a hydroperoxo model for Ni-A is also quite viable, whereas the best model for Ni-B has only a μ-OH bridge. In addition, a mechanism for the activation of unready hydrogenase is proposed on the basis of the relative stabilities of sulfenate models versus peroxide models.
Palabras clave:[NiFe] hydrogenases - Density functional theory - Oxidized forms - Quantum mechanics
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