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RevistaPlos One
Año2015
Volumen10(11)
Páginas1-20
Internacional

EFFECT OF DIETARY DHA SUPPLEMENTATION ON THE PARTICIPATION OF VASODILATOR FACTORS IN AORTA FROM ORCHIDECTOMIZED RATS

Autores:
Grupos de investigación:Biocatalisis y Bioenergía (GBB)
Effect of Dietary Docosahexaenoic Acid
Supplementation on the Participation of
Vasodilator Factors in Aorta from
Orchidectomized Rats
Diva M. Villalpando1,2☯, Rocío Navarro1,2☯, Lara del Campo1,2☯, Carlota Largo3,
David Muñoz4, María Tabernero3, Ramiro Baeza5, Cristina Otero5, Hugo S. García6,
Mercedes Ferrer1,2*
 
Abstract
Benefits of n-3 polyunsaturated fatty acids (PUFAs) against cardiovascular diseases have
been reported. Vascular tone regulation is largely mediated by endothelial factors whose
release is modulated by sex hormones. Since the incidence of cardiovascular pathologies
has been correlated with decreased levels of sex hormones, the aim of this study was to
analyze whether a diet supplemented with the specific PUFA docosahexaenoic acid (DHA)
could prevent vascular changes induced by an impaired gonadal function. For this purpose,
control and orchidectomized rats were fed with a standard diet supplemented with 5% (w/w)
sunflower oil or with 3% (w/w) sunflower oil plus 2% (w/w) DHA. The lipid profile, the blood
pressure, the production of prostanoids and nitric oxide (NO), and the redox status of biological
samples from control and orchidectomized rats, fed control or DHA-supplemented diet,
were analyzed. The vasodilator response and the contribution of NO, prostanoids and
hyperpolarizing mechanisms were also studied. The results showed that orchidectomy negatively
affected the lipid profile, increased the production of prostanoids and reactive oxygen
species (ROS), and decreased NO production and the antioxidant capacity, as well as
the participation of hyperpolarizing mechanisms in the vasodilator responses. The DHAsupplemented
diet of the orchidectomized rats decreased the release of prostanoids and
ROS, while increasing NO production and the antioxidant capacity, and it also improved the
lipid profile. Additionally, it restored the participation of hyperpolarizing mechanisms by activating
potassium. Since the modifications induced by the DHA-supplemented diet were
observed in the orchidectomized, but not in the healthy group, DHA seems to exert cardioprotective
effects in physiopathological situations in which vascular dysfunction exists.

Palabras clave:DHA, essential acids, cardiovascular health
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