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RevistaPlos One
Año2017
Volumen12 (1)
Páginas
Internacional

Docosahexaenoic acid supplemented diet influences the orchidectomy-induced vascular dysfunction in rat mesenteric arteries

Autores:Cristina Otero Hernández
Grupos de investigación:Biocatalisis y Bioenergía (GBB)
Docosahexaenoic Acid Supplemented Diet
Influences the Orchidectomy-Induced
Vascular Dysfunction in Rat Mesenteric
Arteries
Diva M. Villalpando1,2, RocõÂo Navarro1, Lara del Campo1,2, Carlota Largo3, David Muñoz4,
MarõÂa Tabernero3, Ramiro Baeza5, Cristina Otero5, Hugo S. GarcõÂa6, Mercedes Ferrer1,2*
 
Abstract
Over the past few decades, the cardiovascular benefits of a high dietary intake of long-chain
polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA), have been extensively
studied. However, many of the molecular mechanisms and effects exerted by PUFAs
have yet to be well explained. The lack of sex hormones alters vascular tone, and we have
described that a DHA-supplemented diet to orchidectomized rats improve vascular function
of the aorta. Based on these data and since the mesenteric artery importantly controls the
systemic vascular resistance, the objective of this study was to analyze the effect of a DHAsupplemented
diet on the mesenteric vascular function from orchidectomized rats. For this
purpose mesenteric artery segments obtained from control, orchidectomized or orchidectomized
plus DHA-supplemented diet were utilized to analyze: (1) the release of prostanoids,
(2) formation of NO and ROS, (3) the vasodilator response to acetylcholine (ACh), as well as
the involvement of prostanoids and NO in this response, and (4) the vasoconstrictor response
to electrical field stimulation (EFS), analyzing also the effect of exogenous noradrenaline
(NA), and the NO donor, sodium nitroprusside (SNP). The results demonstrate beneficial
effects of DHA on the vascular function in orchidectomized rats, which include a decrease in
the prostanoids release and superoxide formation that were previously augmented by orchidectomy.
Additionally, there was an increase in endothelial NO formation and the response
to ACh, in which NO involvement and the participation of vasodilator prostanoids were
increased. DHA also reversed the decrease in EFS-induced response caused by orchidectomy.
All of these findings suggest beneficial effects of DHA on vascular function by reversing
the neurogenic response and the endothelial dysfunction caused by orchidectomy.

Palabras clave:Omega-3, DHA, essential acids, cardiovascular health
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