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RevistaThe FASEB Journal
Año2017
Volumen31(1)
PáginasSupplement 1017.6 (2017)
Internacional

Spirulina extracts improve vascular function of arteries with vascular damage

Autores:Carlos Manuel Verdasco Martín, Cristina Otero Hernández
Grupos de investigación:Biocatalisis y Bioenergía (GBB)
Spirulina Extracts Improve Vascular Function of Arteries with Vascular Damage
M. Teresa Alameda1, Mireya Ruiz1, Diva M. Villalpando1, Carlos M. Verdasco-Martín2, Ignacio Plaza3, Cristina Otero2 and Mercedes Ferrer1,4
 
Abstract
Vascular dysfunction is characterized by an unbalance between relaxing and
contracting factors, usually in favor of the latest ones, that maintained along the
time could lead to cardiovascular diseases, such as hypertension. On the other
hand, organ culture has been described to induce phenotypic changes in
endothelial cells similar to those observed in some cardiovascular pathologies. In
both hypertension and in organ culture-induced vascular damage, the release and
action of nitric oxide (NO) play a pivotal role in the control of vascular function.
Recently, increasing attention is paying to the use of the microalgae Spirulina for
nutritional interventions due to antioxidant and anti-inflammatory properties.
Therefore, the aim of this study was to analyze the effects of aqueous Spirulina
extract on the release and function of NO in these two experimental models of
vascular dysfunction. For this purpose, thoracic aorta from Sprague-Dawley (SD),
spontaneously hypertensive rats (SHR) and its normotensive Wistar-Kyoto (WKY)
rats (18–20 weeks old) were used. Organ culture-induced vascular damage was
obtained by incubating aortic segments from SD rats for 20 hours at 37° C in
serum free culture medium, and the effect of aqueous Spirulina extract (0.1 % w/v;
for 3 h) on the NO release and on the vasodilation induced by acetylcholine (Ach)
were analyzed. In aortic segments from SHR and WKY rats, the effect of Spirulina
extract on NO release and on the Ach-induced response in endothelium-intact and endothelium-denuded arteries were investigated. The results showed that the
induced vascular damage strongly increased the release of NO, while the
incubation with the Spirulina extract decreased that release up to similar levels
found in intact arteries. The Ach-induced response was not modified after vascular
damage or Spirulina incubation. In aortic segments from SHR and WKY rats
Spirulina extracts increased the release of NO more in arteries from SHR than that
of WKY rats. In endothelium-intact arteries, Spirulina extracts increased more the
Ach-induced response in WKY rats than in those of SHR. Conversely, in
endothelium-denuded arteries, Spirulina increased the Ach-induced relaxation
more in SHR than in those of WKY rats. These findings indicate the beneficial role
of Spirulina extracts on the NO participation in the vasodilator responses of these
two experimental models of vascular dysfunction, although endotheliumindependent
mechanisms are also involved.
Palabras clave:antioxidant, spirulina, cardiovascular function, antihipertensive
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