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PublicationChemPhysLip
Year2015
Volume185
Pages141-152
International

“Modeling the interplay between protein and lipid aggregation in supported membranes

Authors:Pablo GonzalezdePradoSalas , Mario Encinar del Pozo, Alvaro Alonso , Marisela Vélez Tirado, Pedro Tarazona
Groups of research:Biofunctional surfaces laboratory
We presentatheoreticalmodelthatdealswiththecomplexinterplaybetweenlipidsegregationandthe
self-aggregation oflipid-attachedproteins.Themodel,incontrasttopreviousonesthatconsiderproteins
only aspassiveelementsaffectingthelipiddistribution,describesthesystemincludingthreeterms:the
dynamic interactionsbetweenproteinmonomers,theinteractionsbetweenlipidcomponents,anda
mixed termconsideringprotein–lipidinteractions.Itisusedtoexplainexperimentalresultsperformed
on awell-definedsysteminwhichaself-aggregatingsolublebacterialcytoskeletalproteinpolymerizes
on alipidbilayercontainingtwolipidcomponents.Alltheelementsconsideredinapreviouslydescribed
protein model,includingtorsionofthemonomerswithinthefilament,areneededtoaccountforthe
observed filamentshapes.Themodelalsopointsoutthatlipidsegregationcanaffectthelengthand
curvature ofthefilamentsandthatthedynamicbehaviorofthelipidsandproteinscanhavedifferent
time scales,givingrisetomemoryeffects.Thissimplemodelthatconsidersadynamicproteinassembly
on afluidandactivelipidsurfacecanbeeasilyextendedtootherbiologicallyrelevantsituationsinwhich
the interplaybetweenproteinandlipidaggregationisneededtofullydescribethesystem.
Keywords:atomic force microscopy, Theoretical model, Lipid domains, Dynamic protein filaments, Protein–lipid interactions, Supported bilayers
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