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RevistaChemPhysLip
Año2015
Volumen185
Páginas141-152
Internacional

“Modeling the interplay between protein and lipid aggregation in supported membranes

Autores:Pablo GonzalezdePradoSalas , Mario Encinar del Pozo, Alvaro Alonso , Marisela Vélez Tirado, Pedro Tarazona
Grupos de investigación:Laboratorio de Biofuncionalización de Superficies
Pablo González de Prado Salas, Mario Encinar, Alvaro Alonso, Marisela Vélez, Pedro Tarazona
“Modeling the interplay between protein and lipid aggregation in supported membranes" ChemPhysLip
2015,
We presentatheoreticalmodelthatdealswiththecomplexinterplaybetweenlipidsegregationandthe
self-aggregation oflipid-attachedproteins.Themodel,incontrasttopreviousonesthatconsiderproteins
only aspassiveelementsaffectingthelipiddistribution,describesthesystemincludingthreeterms:the
dynamic interactionsbetweenproteinmonomers,theinteractionsbetweenlipidcomponents,anda
mixed termconsideringprotein–lipidinteractions.Itisusedtoexplainexperimentalresultsperformed
on awell-definedsysteminwhichaself-aggregatingsolublebacterialcytoskeletalproteinpolymerizes
on alipidbilayercontainingtwolipidcomponents.Alltheelementsconsideredinapreviouslydescribed
protein model,includingtorsionofthemonomerswithinthefilament,areneededtoaccountforthe
observed filamentshapes.Themodelalsopointsoutthatlipidsegregationcanaffectthelengthand
curvature ofthefilamentsandthatthedynamicbehaviorofthelipidsandproteinscanhavedifferent
time scales,givingrisetomemoryeffects.Thissimplemodelthatconsidersadynamicproteinassembly
on afluidandactivelipidsurfacecanbeeasilyextendedtootherbiologicallyrelevantsituationsinwhich
the interplaybetweenproteinandlipidaggregationisneededtofullydescribethesystem.

Palabras clave:atomic force microscopy, Theoretical model, Lipid domains, Dynamic protein filaments, Protein–lipid interactions, Supported bilayers
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