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PublicationChemical Medicinal Chemistry
Year2014
Volume21
Pages 2299 - 2321
International

Antimicrobial peptides: Promising antibiotic compounds against pathogenic microorganisms

Authors:Roberto Fernandez-Lafuente
Groups of research:Optimización de biocatalizadores y bioprocesos enzimáticos
1Jenniffer Cruz, 2Claudia Ortiz, 3Fanny Guzmán, 4,*Roberto Fernández-Lafuente and 1,*Rodrigo Torres.
 
 
1Grupo de Investigación en Bioquímica y Microbiología (GIBIM), Escuela de Química, Universidad Industrial de Santander, Edificio Camilo Torres 202, Bucaramanga, Colombia
2Grupo de Investigación en Bioquímica y Microbiología (GIBIM), Escuela de Bacteriología y Laboratorio Clínico, Universidad Industrial de Santander, Edificio Camilo Torres 202, Bucaramanga, Colombia.
3NBC Núcleo Biotecnología Curauma, Pontificia Universidad Católica de Valparaíso, Campus Curauma, Av. Universidad, 330 Valparaíso, Chile.
4Departamento de Biocatálisis, Instituto de Catálisis y Petroleoquímica (ICP-CSIC), Campus Universidad Autónoma, Cantoblanco, Madrid, Spain.
Abstract
 

In the last decades, the indiscriminate use of conventional antibiotics has generated high rates of microbial resistance. This situation has increased the need for obtaining new antimicrobial compounds against infectious diseases. Among these, antimicrobial peptides (AMPs) constitute a promising alternative as therapeutic agents against various pathogenic microbes. These therapeutic agents can be isolated from different organisms, being widespread in nature and synthesized by microorganisms, plants and animals (both invertebrates and vertebrates). Additionally, AMPs are usually produced by a non-specific innate immune response. These peptides are involved in the inhibition of cell growth and in the killing of several microorganisms, such as bacteria, fungi, enveloped viruses, protozoans and other parasites. They have many interesting properties as potential antibiotics, such as relatively small sizes (below 25-30 kDa), amphipathic structures, cationic nature, and offer low probability for the generation of microbial resistance. In recent years, many novel AMPs, with very promising therapeutic properties, have been discovered. These peptides have been the base for the production of chemical analogs, which have been designed, chemically synthesized and tested in vitro for their antimicrobial activity. This review is focused on antibacterial (against Gram (-) and Gram (+) bacteria) and antifungal peptides, discussing action mode of AMPs, and recent advances in the study of the molecular basis of their anti-microbial activity. Finally, we emphasize on their current pharmacological development, future directions and applications of AMPs as promising antibiotics of therapeutic use for microbial infections.
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