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PublicationPhysChemChemPhys
Year2011
Volume13
Pages4507-4513
International

Towards biochemical filters with a sigmoidal response to pH changes: buffered biocatalytic signal transduction

Authors:Marcos Pita Martínez, Vladimir Privman , Mary A. Arugula , Dmitriy Melnikov , Vera Bocharova , Evgeny Katz
Groups of research:BioElectroCatalysis
We realize a biochemical filtering process by introducing a buffer in a biocatalytic
signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl
butyrate, is converted into butyric acid—the output signal, which in turn is measured by the drop
in the pH value. The developed approach offers a versatile ‘‘network element’’ for increasing the
complexity of biochemical information processing systems. Evaluation of an optimal regime for
quality filtering is accomplished in the framework of a kinetic rate-equation model.
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