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PublicationNature Chemical Biology
Year2013
Volume9
Pages15-+
International

O-2-independent formation of the inactive states of NiFe hydrogenase

Authors:Abbas Abou Hamdan , Benedicte Burlat , Gutiérrez-Sanz, Oscar, Pierre-Pol Liebgott , Carole Baffert , Antonio López de Lacey, Marc Rousset , Bruno Guigliarelli , Christophe Leger , Sebastien Dementin
Groups of research:BioElectroCatalysis
We studied the mechanism of aerobic inactivation of Desulfovibrio fructosovorans nickel-iron (NiFe) hydrogenase by quantitatively examining the results of electrochemistry, EPR and FTIR experiments. They suggest that, contrary to the commonly accepted mechanism, the attacking O-2 is not incorporated as an active site ligand but, rather, acts as an electron acceptor. Our findings offer new ways toward the understanding of O-2 inactivation and O-2 tolerance in NiFe hydrogenases.
Keywords:CRYSTAL-STRUCTURE, DESULFOVIBRIO-GIGAS HYDROGENASE, ALLOCHROMATIUM-VINOSUM, CATALYTIC CYCLE, CHROMATIUM-VINOSUM, AQUIFEX-AEOLICUS, ACTIVE-SITE, ACTIVATION, NICKEL, UNREADY
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