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Improved enzyme for metabolites and drug synthesis

2016
The Institute of Catalysis and Petrochemistry has generated a proteic variation of the peroxigenase from the Agrocybe aegerita fungi, with enhanced properties of catalytic activity, stability and heterologous expression capacity. The mutant enzyme has been designed to be applied in aromatic hydroxylation reactions, especially for 5’-hydroxipropranolol synthesis. Enzyme producers, or pharma companies, interested in the use of this enzyme for the production of human drug metabolites and other drugs, under patent license, are sought.

Biocatalyst for 1-naphthol production

2016
The CSIC, through its Institute of Catalysis and Petrochemistry, has generated a proteic variation of the peroxigenase from the Agrocybe aegerita fungi, with enhanced properties of catalytic activity, stability and heterologous expression capacity. The mutant enzyme has been designed to be applied in aromatic hydroxylation reactions, especially for 1-naphthol synthesis, being a green alternative to the traditional chemical process.
Companies interested in the enzymatic production of 1-naphthol using this biocatalyst, under patent license, are sought.

High redox potential lacases

2010
A Spanish Institute has developed a process to produce fungal laccases with high-redox potential by directed evolution and expression in yeast. A mutant laccase thus produced shows high activity (6-fold higher than that of similar laccases) and stability to the presence of organic solvents, temperature (T50=73ºC) and pH (pH=3-9) and is secreted at 8 mg/ml of broth.
Exploitation of this OB-1 laccase and other obtainable with this procedure is offered under a patent licence.
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