Born: 1978 at Tenerife, Spain


2001: M. Sc. in Chemical Sciences, Complutense University of Madrid (Spain), Specialist in Foundamental Chemistry.

2006: Ph. D. in Applied Physical Chemistry by the Madrid Autonomic University, Spain.

Research Experience:

2001-06: Catalysis and Petroleum-chemistry Institute, CSIC. Development of the Thesis "Nanoparticles Engineering for the oriented immobilization of biomolecules".

2007-2009: Research Associate and Research Assistant Professor at Clarkson University, Potsdam (NY), USA, in the group of Professor Evgeny Katz.

2010-: Tenure-track Researcher in the Ramón y Cajal Program, at the Catalysis and Petroleum-chemistry Institute, CSIC.

Research Interests:

Biofunctionalized nanomaterials (metallic nanoparticles, magnetic nanoparticles, semiconductive quantum dots, nanorods, nanowires) for bioelectronic and biomedical applications.
Bionanoengineering, functional interfaces composed of biomaterials & nano-objects, supra-molecular hybrid systems with complex molecular/biomolecular architecture;
Bioelectronics & optobioelectronics, switchable & tunable electrobiocatalytic and photobiocatalytic systems;
Bionanotechnology for bioelectronic applications, electrical wiring of enzymes by nano-objects, amplification paths for bioanalytical systems, nanocircuitry generation based on biotemplates & biocatalysis;
Biosensors based on integrated systems with complex molecular architecture, self-powered biosensors, switchable & tunable biosensors;
Amplified DNA-sensors and immunosensors, amplification systems based on bioelectronics and bionanotechnology, DNA-arrays and biorecognition arrays;
Biofuel cells engineering, biofuel cells based on integrated bioelectrocatalytic systems;
Biocomputing based on enzymes and DNA, logical gates and arithmetics based on bioelectronic systems, self-organized & self-responding bioelectronic systems.


Dr. Marcos Pita.

Publications (Índice H = 15, Julio 2010)

61. M. Pita, J. Halámek, E. Katz. “Electrochemical systems controlled by enzyme-based logic networks: Towards biochemicaly controlled bioelectronics.” Electrochemical Processes in Biological Systems, L. Gorton, A. Lewenstam (Eds.), Wiley, 2011, in press.

60. Marcos Pita, Antonio L. DeLacey. "Métodos electroanalíticos". Ed. Departamento de Publicaciones del CSIC, Madrid, 2011, in press.

59. Sergiy Minko, Evgeny Katz, Mikhail Motornov, Ihor Tokarev, Marcos Pita. “Materials with Built-in Logic” Journal of Computational and Theoretical Nanoscience, 2011, in press.

58. Marcos Pita, Evgeny Katz. “Biocatalytic paradigms for unconventional information processing”. Journal of Computational and Theoretical Nanoscience, 2011, in press.

57. Marcos Pita, Vladimir Privman, Mary A. Arugula, Dmitriy Melnikov, Vera Bocharova, Evgeny Katz. “Towards Biochemical Filter with Sigmoidal Response to pH Changes: Buffered Biocatalytic Signal Transduction” Physical Chemistry Chemical Physics, 2011, 13, 4507-4513.

56. Valber Pedrosa, Dmitriy Melnikov, Marcos Pita, Jan Halámek, Vladimir Privman, Aleksandr Simonian, Evgeny Katz. “Enzymatic Logic Gates with Noise-reducing Sigmoid Response” Journal of Unconventional Computing, 2010, 6 (6), 451-460.

55. Mary A. Arugula, Vera Bocharova, Jan Halámek, Marcos Pita, Evgeny Katz. “Enzyme-based multiplexer and demultiplexer”. Journal of Physical Chemistry B, 2010, 114 (15), 5222-5226.

54. Jan Halámek, Tsz Kin Tam, Guinevere Strack, Vera Bocharova, Marcos Pita, Evgeny Katz. “Self-powered biomolecular keypad lock security system based on a biofuel cell.” Chemical Communications 2010, (14), 2405-2407.
Article highlighted in Royal Society of Chemistry

53. Vera Bocharova, Tsz Kin Tam, Jan Halámek, Marcos Pita, Evgeny Katz. “Reversible Gating Controlled by Enzymes at Nanostructured Interface”. Chemical Communications, 2010, 46, 2088–2090.

52. Guinevere Strack, Vera Bocharova, Mary A. Arugula, Marcos Pita, Jan Halámek, Evgeny Katz. “Artificial Muscle Reversibly Controlled by Enzyme Reactions”. Journal of Physical Chemistry Letters 2010, 1 (5), 839–843.

51. Tsz Kin Tam, Marcos Pita, Oleksandr Trotsenko, Mikhail Motornov, Ihor Tokarev, Jan Halámek, Sergiy Minko, Evgeny Katz. “Reversible “Closing” of an Electrode Interface Functionalized with a Polymer Brush by an Electrochemical Signal”. Langmuir, 2010, 26 (6), 4506–4513.

50. Tsz Kin Tam, Marcos Pita, Mikhail Motornov, Ihor Tokarev, Sergiy Minko, Evgeny Katz. “Electrochemical Nanotransistor from Mixed Polymer Brush”, Advanced Materials, 2010, 22 (16), 1863-1866.

49. Valeriya Bychkova, Alexey Shvarev, Jian Zhou, Marcos Pita, Evgeny Katz. “Enzyme Logic Gate Associated with a Single Responsive Microparticle: Scaling Biocomputing to Microsize Systems”. Chemical Communications, 2010, 46, 94-96.

48. Tsz Kin Tam, Marcos Pita, Mikhail Motornov, Ihor Tokarev, Sergiy Minko, Evgeny Katz. “Modified Electrodes with Switchable Selectivity for Cationic and Anionic Redox Species”. Electroanalysis, 2010, 22(1), 35-40.

47. Marcos Pita, Guinevere Strack, Kevin MacVittie, Jian Zhou, Evgeny Katz. “Set-Reset Flip-Flop Memory Based on Enzyme Reactions: Towards Memory Systems Controlled by Biochemical Pathways”. Journal of Physical Chemistry B, 2009, 113 (49), 16071–16076.

46. Mary A. Arugula, Jan Halámek, Evgeny Katz, Dmitriy Melnikov, Marcos Pita, Vladimir Privman, Guinevere Strack. “Optimization of Enzymatic Logic Gates and Networks for Noise Reduction and Stability”. IEEE Comp. Soc. Publ. (Los Alamitos, California) 2009, 1-7.
Achieved the “Best Paper Award” by the International Academy, Research, and Industry Association when presented at CENICS 2009 in Sliema, Malta, October 11-16, 2009.

45. M. El-Hilo, J. Al Saie, M.P. Morales, M. Pita. “Simple Technique For Texture Function Analysis in Granular Thin Film Media”. Physica B, 2009, 404, 3991-3994.

44. Jian Zhou, Mary A. Arugula, Jan Halámek, Marcos Pita, Evgeny Katz. “Enzyme-Based NAND and NOR Logic Gates with Modular Design”. Journal of Physical Chemistry B, 2009, 113 (49), 16065–16070.

43. Evgeny Katz, Marcos Pita. “Biofuel Cells Controlled by Logically Processed Biochemical Signals: Towards Physiologically Regulated Bioelectronic Devices”. Concept paper in Chemistry: an European Journal, 2009, 15, 12554-12564.

42.   Vladimir Privman, Valber Pedrosa, Dmitriy Melnikov, Marcos Pita, Aleksandr Simonian, Evgeny Katz. “Enzymatic AND-Gate Based on Electrode-Immobilized Glucose-6-Phosphate Dehydrogenase: Towards Digital Biosensors and Biochemical Logic Systems with Low Noise”. Biosensors and Bioelectronics, 2009, 25 (4), 695-701.

41.   Cristina Vaz, Susana Campuzano, Víctor M. Fernández, Marcos Pita. “Nanostructured DNA biosensors based on artificial nucleic acid analogues”. Fabrication and Bio-Application of Functionalized Nanomaterials 7, p. 207-228,  2009. X. Wang (ed), Research Signpost, Kerala, India.

40.   Mikhail Motornov, Tsz Kin Tam, Marcos Pita, Ihor Tokarev, Evgeny Katz, Sergiy Minko.“Switchable selectivity in gating of ion transport with mixed polyelectrolyte brushes for smart delivery systems”. Nanotechnology, 2009, 20 (43), 434006-434016.

39.   Xuemei Wang, Jian Zhou, Tsz Kin Tam, Evgeny Katz, Marcos Pita. “Switchable Electrode Controlled by Boolean Logic Gates Using Enzymes as Input Signals”. Bioelectrochemistry, 2009, 77(1), 69-73.

38.   Tsz Kin Tam, Guinevere Strack, Marcos Pita, Evgeny Katz. “Biofuel Cell Logically Controlled by Antigen-Antibody Recognition: Towards Immune-Regulated Bioelectronic Devices”. Journal of the American Chemical Society,  2009, 131 ( 33), 11670–11671.

37.   Guinevere Strack, Soujanya Chinnapareddy, Dmytro Volkov, Jan Halámek, Marcos Pita, Igor Sokolov, Evgeny Katz. “Logic Networks Based on Immunorecognition Processes”. Journal of Physical Chemistry B,  2009, 113 (35), 12154–12159.

36.   Dmitriy Melnikov, Guinevere Strack, Marcos Pita, Vladimir Privman, Evgeny Katz.“Analog Noise Reduction in Enzymatic Logic Gates”. Journal of Physical ChemistryB,  2009, 113 (30), pp 10472–10479.

35.   Xuemei Wang, Jian Zhou, Tsz Kin Tam, Evgeny Katz, Marcos Pita. “Switchable Electrode Controlled by Boolean Logic Gates Using Enzymes as Input Signals”. Bioelectrochemistry, 2009, in press.

34.   Kalayil Manian Manesh, Jan Halámek, Marcos Pita, Jian Zhou, Tsz Kin Tam, Padmanabhan Santhosh, Min-Chieh Chuang, Joshua R. Windmiller, Dewi Abidin, Evgeny Katz and Joseph Wang. “Enzyme Logic Gates for the Digital Analysis of Physiological Level upon Injury”. Biosensors & Bioelectronics,  2009,  24, 3569–3574.

33.   Marcos Pita, Tsz Kin Tam, Sergiy Minko and Evgeny Katz. “Dual Magneto-Biochemical Logic Control of Electrochemical Processes Based on Local Interfacial pH Changes” ACS Applied Materials & Interfaces,  2009, 1 ( 6), pp 1166–1168.

32.   Tsz Kin Tam, Marcos Pita, Evgeny Katz. “Enzyme Logic Network Analyzing Combinations of Biochemical Inputs and Producing Fluorescent Output Signals: Towards Multi-Signal Digital Biosensors.” Sensor & Actuators B. Chemical,  2009, 140 ( 1), 1-4 .

31.   Marcos Pita, Jian Zhou, Kalayil Manian Manesh, Jan Halámek, Evgeny Katz, Joseph Wang.“Enzyme Logic Gates for Assessing Physiological Conditions During an Injury.” Sensors and Actuators B: Chemical,  2009, 139 ( 2), 631-636.

30.   Jian Zhou, Galina Melman, Marcos Pita, Artem Melman and Evgeny Katz. “Biomolecule Oxidative Damage Activated by Enzyme Logic Systems: Biologically Inspired Approach.”ChemBioChem,  2009,  10 ( 6), 1084-1090 .

29.   Ihor Tokarev, Venkateshwarlu Gopishetty, Jian Zhou, Marcos Pita, Mikhail Motornov, Evgeny Katz, Sergiy Minko. “Stimuli-Responsive Hydrogel Membranes Coupled with Biocatalytic Processes”. ACS Applied Materials & Interfaces,  2009, 1 (3), pp 532–536 .

28.   Tsz Kin Tam, Marcos Pita, Maryna Ornatska, Evgeny Katz. “Biofuel Cell Controlled by Enzyme Logic Network – Approaching Physiologically Regulated Devices”. Bioelectrochemistry,  2009, in press.

27.   Vladimir Privman, Mary A. Arugula, Jan Halámek, Marcos Pita, Evgeny Katz. “Network Analysis of Biochemical Logic for Noise Reduction and Stability: A System of Three Coupled Enzymatic AND Gates”. The Journal of Physical Chemistry,  2009, 113 (15), 5301–5310.

26.   Marina Privman, Tsz Kin Tam, Marcos Pita, Evgeny Katz. “Switchable Electrode Controlled by Biocomputing Network System: Approaching Physiologically Regulated Bioelectronics”. Journal of the American Chemical Society,  2009, 131 (3), pp 1314–1321 .

25.   Melina Krämer, Marcos Pita, Jian Zhou, Maryna Ornatska, Arshak Poghossian, Michael J. Schöning, Evgeny Katz. “Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information” Journal of Physical Chemistry,  200 9,  113 (6), pp 2573–2579 .

24.   Mikhail Motornov, Jian Zhou, Marcos Pita, Ihor Tokarev, Venkateshwarlu Gopishetty, Evgeny Katz, Sergiy Minko. “Integrated Multifunctional Nanosystem from Command Nanoparticles and Enzymes”, Small,  2009,  5 ( 7), 817-820.

23.   Jian Zhou, Tsz Kin Tam, Marcos Pita, Maryna Ornatska, Sergiy Minko, Evgeny Katz.“Bioelectrocatylic System Coupled with Enzyme-Based Biocomputing Ensembles Performing Boolean Logic Operations: Approaching “Smart” Physiologically Controlled Bioelectrodes”.ACS Applied Materials & Interfaces,  2009,  1 ( 1), pp 144–149.

22.   Liron Amir, Tsz Kin Tam, Marcos Pita, Michael M. Meijler, Lital Alfonta, Evgeny Katz.“Biofuel Cell Controlled by Enzyme Logic Systems”. Journal of the American Chemical Society,  2009, 131 (2), pp 826–832 .

21 Marcos Pita, Evgeny Katz. “Switchable Electrodes: How Can the System Complexity be Scaled Up?” . Electroanalysis,  2009, 21( 3-5), 252-260.

20.   Marcos Pita, Melina Krämer, Jian Zhou, Arshak Poghossian, Michael J. Schöning, Víctor M. Fernández, Evgeny Katz. “Optoelectronic Properties of Nanostructured Ensembles Controlled by Biomolecular Logic Systems”. ACS Nano,  2008, 2(10); 2160-2166.

19.   Tsz KinTam, Jian Zhou, Maryna Ornatska, Marcos Pita, Sergiy Minko, Evgeny Katz.“Biochemically Controlled Bioelectrocatalytitic Interface”. Journal of the American Chemical Society,  2008, 130 ( 33); 10888-10889.

18.   Mikhail Motornov, Jian Zhou, Marcos Pita,Venkateshwarlu Gopishetty, Ihor Tokarev, Evgeny Katz, Sergiy Minko. ““Chemical Transformers” from Nanoparticle Ensembles Operated with Logic”. Nano Letters,  2008, 8(9); 2993-2997.

Article highlighted in Nature Nanotechnology Research Highlights.

17. Marcos Pita, Sergiy Minko, Evgeny Katz. “Enzyme-Based Logic Systems and their Applications for Novel Multi-Signal-Responsive Materials”. Journal of Materials Science: Materials in Medicine,  2008,  20 ( 2), 457-462.

16.   Marcos Pita, Lili Cui, Ravi M. Gaikwad, Evgeny Katz, Igor Sokolov. “High Sensitivity Molecular Detection with Remote ELISA–Type Immunosensing”. Nanotechnology 19 (2008) 375502 (6pp).

15.   Vladimir Privman, Guinevere Strack, Dmitry Solenov, Marcos Pita, Evgeny Katz.“Optimization of Enzymatic Biochemical Logic for Noise Reduction and Scalability: How Many Biocomputing Gates Can be Interconnected in a Circuit?”, Journal of Physical Chemistry B,  2008, 112(37); 11777-11784.

14.   Cristina Vaz-Dominguez, Susana Campuzano, Olaf Rüdiger, Marcos Pita, Marina Gorbacheva, Sergey Shleev, Victor M. Fernandez, Antonio L. De Lacey. “Enzymatic electrode for direct electrocatalytic reduction of O2 to H2O with high operational stability and resistance to chloride inhibition”. Biosensors and Bioelectronics,  2008, 24, 531–537.

13.   Javier Jiménez, Roman Sheparovych, Marcos Pita, Arántzazu García, Elena Dominguez, Sergiy Minko, Evgeny Katz. "Magneto-induced Self-assembling of Conductive Nanowires for Biosensor Applications", Journal of Physical Chemistry C, 2008; 112(19); 7337-7344.

12.   Tam Tsz Kin, Maryna Ornatska, Marcos Pita, Sergiy Minko, Evgeny Katz. “Polymer Brush-Modified Electrode with Switchable and Tunable Redox Activity for Bioelectronic Applications”, Journal of Physical Chemistry C,  2008; 112(22); 8438-8445.

11.   Guinevere Strack, Maryna Ornatska, Marcos Pita, Evgeny Katz. “Biocomputing Security System: Concatenated Enzyme-Based Logic Gates Operating as a Biomolecular Keypad Lock”, Journal of the American Chemical Society,  2008; 130(13); 4234-4235.

Article marked by the editor as top contribution

Article highlighted in press releases:


10.   Guinevere Strack, Marcos Pita, Marina Ornatska, Evgeny Katz. “Boolean Logic Gates Using Enzymes as Input Signals”, Chem. Bio. Chem.  2008, 130 (9), 1260-1266.

9.   Marcos Pita, José M. Abad, Cristina Vaz-Dominguez, Carlos Briones, Eva Mateo-Martí, José A. Martín-Gago, María del Puerto Morales, Víctor M Fernández. “Synthesis of Cobalt Ferrite Core /Metallic Shell Magnetic Nanoparticles for the Development of a Specific PNA/DNA Biosensor”, Journal of Colloid Interface Science,  2008,  321, 484-492.

8.   Marcos Pita, Evgeny Katz. “Multiple Logic Gates Based on Electrically Wired Surface-Reconstituted Enzymes”. Journal of the American Chemical Society,  2008, 130(1), 36-37.

7.   Sergey Vasiylev, Marcos Pita, Evgeny Katz. “Logic Gates Based on Magnetic Nanoparticles Functionalized with a Bioelectrocatalytic System.” Electroanalysis  2008,  1, 22-29.

6.   Sergey Shleev, Marcos Pita, Alexander I. Yaropolov, Tautgirdas Ruzgas, Lo Gorton. “Direct heterogeneous electron transfer reactions of Trametes hirsuta laccase at bare and thiol-modified gold electrodes”. Electroanalysis  2006,  18, 1901-1908.

5.   Ana Beloqui, Marcos Pita, Julio Polaina, Arturo Martínez-Arias, Olga V. Golyshina, Miren Zumárraga, Michail M. Yakimov, Humberto García-Arellano, Miguel Alcalde, Víctor M. Fernández, Kieran Elborough, José M. Andreu, Antonio Ballesteros, Francisco J. Plou, Kenneth N. Timmis, Manuel Ferrer, and Peter N. Golyshin. “Novel Polyphenol Oxidase Mined From A Metagenome Expresion Library Of Bovine Rumen: Biochemical Properties, Structural Analysis And Phylogenetic Relationships”, Journal of Biological Chemistry  2006, 281, 22933-22942.

4.   Marcos Pita, Sergey Shleev, Tautgirdas Ruzgas, Víctor M. Fernández, Alexander I. Yaropolov, Lo Gorton. “Direct heterogeneous electron transfer reactions of fungal laccases at bare and thiol-modified gold electrodes”. Electrochemistry Communications  2006,  8, 747-753.

3.   José M. Abad, Marcos Pita, Víctor M. Fernández. “Immobilization of Proteins on Gold Surfaces”. Methods in Biotechnology 22, p. 229-238,  2006. J.M. Guisan (ed), Humana Press Inc., Totowa, NJ.

2.   José M. Abad, Stijn F. L. Mertens, Marcos Pita, Victor M. Fernández, David J. Schiffrin.“Functionalization of Thioctic Acid-Capped Gold Nanoparticles for Specific Immobilization of Histidine-Tagged Proteins”. Journal of the American Chemical Society;  2005, 127(15), 5689-5694. (65 cites in April 2010) .

1.   Ana M. Rubio, Marcos Pita, Juan J. Freire. "Cyclization Kinetics of Nondiluted Bond Fluctuation Chains" Macromolecules;  2002,  35, 5681-5687.