Applied Biocatalysis Group
It's all possible with enzymes
ANTIOXIDANTS
Antioxidants protect cells against the effects of harmful free radicals and play an important role in preventing many human diseases (e.g. cancer, atherosclerosis, stroke, diabetes, rheumatoid arthritis, neurodegeneration,inflammatory disorders) and aging itself .
The modification of natural antioxidants to improve their chemical, oxidative or thermal stability, bioavailability and/or pharmaceutical efficacy yields a series of “semisynthetic” antioxidants (e.g. tocopheryl acetate, L-ascorbyl palmitate) with great impact in the industry.
PUBLICATIONS
Enzymatic modification of natural antioxidants
“Synthesis and Properties of Ascorbyl Esters Catalyzed by Lipozyme TL IM using Triglycerides as Acyl Donors”. D. Reyes-Duarte, N. Lopez-Cortes, P. Torres, F. Comelles, J. L. Parra, S. Peña, A. V. Ugidos, A. Ballesteros and F. J. Plou. Journal of American Oil Chemists’ Society (2010) |
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| doi: 10.1007/s11746-010-1643-5 |
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| “Antioxidant Activity of Resveratrol in Several Fish Lipid Matrices: Effect of Acylation and Glucosylation”. I. Medina, D. Alcántara, María J. González, P. Torres, R. Lucas, J. Roque, F.J. Plou and J.C. Morales.Journal of Agricultural and Food Chemistry (2010) |
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| doi: 10.1021/jf101472n |
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| “Regioselective Lipase-Catalyzed Synthesis of 3-O-Acyl Derivatives of Resveratrol and Study of Their Antioxidant Properties”. P. Torres, A. Poveda, J. Jimenez-Barbero, A. Ballesteros, and F.J. Plou. Journal of Agricultural and Food Chemistry,58, 807-813 (2010) | |
| doi: 10.1021/jf903210q |
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“Enzymatic modification for ascorbic acid and alpha-tocopherol to enhance their stability in food and nutritional applications”. P. Torres, A. Kunamneni, A. Ballesteros and F.J. Plou. The Open Food Science Journal, 2, 1-9 (2008). |
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| doi: 10.2174/1874256400802010001 |  |
| “Acetylation of vitamin E by Candida antarctica lipase B immobilized on different carriers”. P. Torres, D. Reyes-Duarte, N. López-Cortés, M. Ferrer, A. Ballesteros and F.J. Plou. Process Biochemistry 42, 145-153 (2008). | |
| doi: 10.1016/j.procbio.2007.11.008 | |